Publicaties

AIM: Only 12-49% of colorectal cancer (CRC) patients and their first-degree relatives with an increased familial CRC risk are referred for cancer prevention measures (surveillance colonoscopies or genetic counselling). The study was performed to e...

IMPORTANCE: Although depression and type 2 diabetes mellitus (DM) may independently increase the risk for dementia, no studies have examined whether the risk for dementia among people with comorbid depression and DM is higher than the sum of each ...

Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic testing, surgery, surveillance strategies, pathology reporting a...

Context: Met de steeds groeiende aandacht voor vroegtijdige zorgplanning (VZP) ontstond het initiatief vanuit de Koning Boudewijn Stichting om de recente algemene richtlijn VZP aan te passen aan de doelgroep ‘personen met dementie’. Deel 1 van dez...

Context Vroegtijdige zorgplanning (VZP) staat tegenwoordig in de belangstelling. Recent werd een richtlijn ontwikkeld hoe men het best VZP uitvoert. Hoe men dit het beste aanpakt bij personen met dementie komt hier echter niet in voor. In deel I v...

Background: Acute infection is the most common presentation of children to ambulatory care. In contrast, serious infections are rare and often present at an early stage. To avoid complications or death, early recognition and adequate referral are ...

ACHTERGROND: Vroegtijdige zorgplanning (VZP) is een proces van reflectie en dialoog tussen de patiënt, zijn naasten en één of meerdere zorgverleners (waaronder een arts) waarbij toekomstige zorgdoelen besproken en gepland worden. Deze zorgdoelen z...

AIMS: The association between recent and more distant weight changes before and after the diagnosis of type 2 diabetes has been little researched. The aim of this study is to determine the influence of patients' weight history before diabetes diag...

OBJECTIVE: To assess adherence to expectant management of 6-12 months in couples with unexplained subfertility, as recommended by the Dutch Networkguideline Subfertility. DESIGN: A retrospective cohort study in 25 clinics. METHOD: Couples were eli...

BACKGROUND: Over the last 50 years, clinical research investigating new treatments has been transforming the care of patients with haemophilia but we still have a long way to go and most clinical investigators are facing difficulties in recruiting...

The β-OG pocket is a cavity in the flavivirus envelope (E) protein that was identified by Proc. Natl. Acad. Sci. U.S.A.2003, 100, 6986 as a promising site for the design of antiviral agents that interfere with virus entry into the host cell. The a...

Background: Substance misuse by adolescents is a chronic and important problem. Prevention programs should be aimed to prevent, reduce or delay the use of substances. Aims: The objectives of this umbrella review was to summarizes the results of s...

Background Homecare is facing one of its biggest challenges: the growing imbalance between the increasing demand for care at home and the decreasing supply of home nurses. The demographic and economic evolutions and trends increasingly confront ho...

BACKGROUND: Better biomarkers must be found to develop clinically useful urine tests for bladder cancer. Proteomics can be used to identify the proteins released by cancer cell lines and generate candidate markers for developing such tests. METHOD...

Nursing home residents are frail patients who experience frequent hospital admission with an increased risk for acute confusion, iatrogenic adverse events, nosocomial infections, decline in ADL and death during hospitalization. Avoidance of unnece...

The increasing number of older cancer patients will become an important challenge for healthcare services, as older cancer patients often present with complex combinations of both cancer- and ageing-related problems. Older cancer patients represen...

OBJECTIVES: To describe the level of overdetection people would find acceptable in screening for breast, prostate, and bowel cancer and whether acceptability is influenced by the magnitude of the benefit from screening and the cancer specific harm...

Background: Geriatric screening tools are increasingly implemented in daily practice, especially in the oncology setting, but also in primary care in some countries such as the Netherlands. Nonetheless, validation of these tools regarding their ab...