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Auteurs: Carla Truyers, Stephaan Bartholomeeusen, Gijs Van Pottelbergh, Geert Goderis et Frank Buntinx
1 April 2013 | ARTICLE
Can training improve laypersons helping behaviour in first aid? A randomised controlled deception trial
BACKGROUND: There is limited evidence indicating that laypersons trained in first aid provide better help, but do not help more often than untrained laypersons. This study investigated the effect of conventional first aid training versus conventio...
Auteurs: Stijn Van de Velde, Ann Roex, Karoline Vangronsveld, Lidewij Niezink, Koen Van Praet, Annemie Heselmans, Peter Donceel, Philippe Vandekerckhove, Dirk Ramaekers et Bert Aertgeerts
1 April 2013 | ARTICLE
Spirituality in palliative home care: a framework for the clinician
PURPOSE: Spiritual care at the end of life remains poorly understood, despite its promotion by the World Health Organisation. The purpose of this paper is to develop a consensus based framework of the main elements of spiritual care in palliative ...
Auteurs: Mieke Vermandere, Jan De Lepeleire, Wouter Van Mechelen, Franca Warmenhoven, Bregje Thoonsen et Bert Aertgeerts
1 April 2013 | OTHER
Exploring the Potential for a Consensus on Reporting Guidelines for Qualitative Research using a Delphi Approach
1. PURPOSE OF THE STUDY Reporting guidelines have successfully been developed and disseminated for quantitative research designs such as experimental research, longitudinal research, cross-sectional research and meta-analyses. These guidelines inc...
Auteurs: Karin Hannes, Mieke Heyvaert, Elke Emmers, Stef Van den Brande, Sabine Van Houdt, Karin Slegers et Marc Van Nuland
1 April 2013 | ARTICLE
[How much do patients and health professionals (really) know? The surplus value of a home visit to the patient with polypharmacy by the practice nurse, to support medication reviews in primary care].
BACKGROUND: Polypharmacy in older people should be addressed by an annual review of the chronic medication. In the PIL-study this was done by an integrated approach by GP, practice nurse, pharmacist, specialist and patient. All patients were first...
Auteurs: D Bosch-Lenders, M van den Akker, HEJH Stoffers, H van der Kuy, JMGA Schols et JA Knottnerus
1 April 2013 | ARTICLE
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus
Chikungunya virus (CHIKV) is an Arbovirus that is transmitted to humans primarily by the mosquito species Aedes aegypti. Infection with this pathogen is often associated with fever, rash and arthralgia. Neither a vaccine nor an antiviral drug is a...
Auteurs: Marcella Bassetto, Tine De Burghgraeve, Leen Delang, Alberto Massarotti, Antonio Coluccia, Nicola Zonta, Valerio Gatti, Giampiero Colombano, Giovanni Sorba, Romano Silvestri, Gian Cesare Tron, Johan Neyts, Pieter Leyssen et Andrea Brancale
Auteurs: Mirjam Schreurs, Gijs Van Pottelbergh, K Kiekens et Jean-Marie Degryse
1 April 2013 | ARTICLE
Influence of chronic comorbidity and medication on the efficacy of treatment in patients with diabetes in general practice

Evidence on the influence of comorbidity and comedication on clinical outcomes in patients with type 2 diabetes mellitus is scarce.

Auteurs: Welcome Mkululi Wami, Frank Buntinx, Stefaan Bartholomeeusen, Geert Goderis, Chantal Mathieu et Marc Aerts
1 March 2013 | ARTICLE
Adequaat voorschrijven bij ouderen: een interventiestudie bij ouderen
Context: Adequaat voorschrijven bij ouderen is een uitdaging voor elke arts. Studies rond medicatiebeleid bij ouderen richten zich voornamelijk op polyfarmacie (‘overprescribing’). Dit is echter slechts één deelaspect van de problematiek van het ‘...
Auteurs: Evelien Lenaerts, Floris De Knijf et Birgitte Schoenmakers
1 March 2013 | ARTICLE
3',5'Di-O-trityluridine inhibits in vitro flavivirus replication
The dengue fever virus (DENV) and the yellow fever virus (YFV) are members of the genus flavivirus in the family Flaviviridae. An estimated 50-100 million cases of DENV infections occur each year and approximately half a million patients require h...
Auteurs: Tine De Burghgraeve, Barbara Selisko, Suzanne Kaptein, Grégory Chatelain, Pieter Leyssen, Yannick Debing, Michel Jacobs, Arthur Van Aerschot, Bruno Canard et Johan Neyts
1 March 2013 | ARTICLE
Subjective memory complaints in primary care patients and death from all causes: A four-year follow-up
OBJECTIVE: To investigate the prognostic value of subjective memory complaints for all-cause mortality in order to determine whether elderly persons with subjective memory complaints may be regarded as a group of vulnerable patients who need close...
Auteurs: Volkert Siersma, Gunhild Waldemar et Frans Boch Waldorff
Auteurs: Laura Deckx, Marjan van den Akker, Liesbeth Daniels, Tine De Burghgraeve, Carine Van Den Broeke, Paul Buelens et Frank Buntinx
1 March 2013 | ARTICLE
Nutrient-based dietary patterns and pancreatic cancer risk
PURPOSE: Few data are available on the role of combinations of foods and/or nutrients on pancreatic cancer risk. To add further information on dietary patterns potentially associated to pancreatic cancer, we applied an exploratory principal compon...
Auteurs: Cristina Bosetti, Francesca Bravi, Federica Turati, Valeria Edefonti, Jerry Polesel, Adriano Decarli, Eva Negri, Renato Talamini, Silvia Franceschi, Carlo La Vecchia et Maurice P Zeegers
1 March 2013 | ARTICLE
Defining the Palliative Care Patient: a systematic review.
Background: The lack of a clear definition of the palliative care patient hampers the comparison of results across different studies and impedes implementation of research findings in everyday practice. Aim: The aim of this article is to propose m...
Auteurs: Wouter Van Mechelen, Bert Aertgeerts, Karolien De Ceulaer, Bregje Thoonsen, Mieke Vermandere, Franca Warmenhoven, Eric Van Rijswijck et Jan De Lepeleire
13 February 2013 | ARTICLE
Minimal Intensity Physical Activity (Standing and Walking) of Longer Duration Improves Insulin Action and Plasma Lipids More than Shorter Periods of Moderate to Vigorous Exercise (Cycling) in Sedentary Subjects When Energy Expenditure Is Comparable
BACKGROUND: Epidemiological studies suggest that excessive sitting time is associated with increased health risk, independent of the performance of exercise. We hypothesized that a daily bout of exercise cannot compensate the negative effects of i...
Auteurs: Bernard MFM Duvivier, Nicolaas C Schaper, Michelle A Bremers, Glenn van Crombrugge, Paul PCA Menheere, Marleen Kars et Hans HCM Savelberg
Auteurs: Etienne Declercq, Viviane Van Casteren, Nathalie Bossuyt, Sarah Moreels, Geert Goderis, Stefaan Bartholomeeusen, Pierre Bonte et Marc Bangels
Auteurs: Mieke Deschodt, Johan Flamaing, Patrick Haentjens, Steven Boonen et Koen Milisen
1 February 2013 | ARTICLE
Guideline adherence is worth the effort: a cost-effectiveness analysis in intrauterine insemination care
STUDY QUESTION: Is optimal adherence to guideline recommendations in intrauterine insemination (IUI) care cost-effective from a societal perspective when compared with suboptimal adherence to guideline recommendations? SUMMARY ANSWER: Optimal guid...
Auteurs: EC Haagen, WLDM Nelen, EM Adang, RPTM Grol, RPMG Hermens et JAM Kremer
1 February 2013 | ARTICLE
Evaluation of an effective multifaceted implementation strategy for elective single-embryo transfer after < /i>in vitro< //i> fertilization
STUDY QUESTION: What is the relationship between the rate of elective single-embryo transfer (eSET) and couples' exposure to different elements of a multifaceted implementation strategy? SUMMARY ANSWER: Additional elements in a multifaceted implem...
Auteurs: IAM Kreuwel, AM van Peperstraten, MEJL Hulscher, JAM Kremer, RPTM Grol, WLDM Nelen et RPMG Hermens
1 February 2013 | ARTICLE
The impact of inpatient geriatric consultation teams on clinical outcome in acute hospital wards: a systematic review and meta-analysis
BACKGROUND: Comprehensive geriatric assessment for older patients admitted to dedicated wards has proven to be beneficial, but the impact of comprehensive geriatric assessment delivered by mobile inpatient geriatric consultation teams remains uncl...
Auteurs: Mieke Deschodt, Johan Flamaing, Patrick Haentjens, Steven Boonen et Koen Milisen
1 February 2013 | ARTICLE
Active acromegaly is associated with decreased hs-CRP and NT-proBNP serum levels: insights from the Belgian registry of acromegaly
Patients with active acromegaly have an increased prevalence of cardiomyopathy and heart failure but a less than expected risk of coronary artery disease, considering the frequent association of diabetes mellitus and hypertension. We examined whet...
Auteurs: Johan Verhelst, Brigitte Velkeniers, Dominique Maiter, Patrick Haentjens, Guy T'Sjoen, Ernst Rietzschel, Bernard Corvilain, Pascale Abrams, Frank Nobels, Roger Abs et Mieke Bex
15 January 2013 | ARTICLE
How well do clinical prediction rules perform in identifying serious infections in acutely ill children across an international network of ambulatory care datasets?
Diagnosing serious infections in children is challenging, because of the low incidence of such infections and their non-specific presentation early in the course of illness. Prediction rules are promoted as a means to improve recognition of seriou...
Auteurs: Jan Verbakel, Ann Van den Bruel, Matthew Thompson, Richard Stevens, Bert Aertgeerts, Rianne Oostenbrink, Henriette A Moll, Marjolein Y Berger, Monica Lakhanpaul, David Mant, Frank Buntinx et European Research Network on Recognising Serious Infection (ERNIE)
3 January 2013 | ARTICLE
SIMPLE: implementation of recommendations from international evidence-based guidelines on caesarean sections in the Netherlands. Protocol for a controlled before and after study
BACKGROUND: Caesarean section (CS) rates are rising worldwide. In the Netherlands, the most significant rise is observed in healthy women with a singleton in vertex position between 37 and 42 weeks gestation, whereas it is doubtful whether an impr...
Auteurs: Sonja Melman, Ellen NC Schoorel, Carmen Dirksen, Anneke Kwee, Luc Smits, Froukje de Boer, Madelaine Jonkers, Mallory D Woiski, Ben Willem J Mol, Johannes PR Doornbos, Harry Visser, Anjoke JM Huisjes, Martina M Porath, Friso MC Delemarre, Simone MI Kuppens, Robert Aardenburg, Ivo MA Van Dooren, Francis PJM Vrouenraets, Frans TH Lim, Gunilla Kleiverda, Paulien CM van der Salm, Karin de Boer, Marko J Sikkema, Jan G Nijhuis, Rosella PMG Hermens et Hubertina CJ Scheepers
1 January 2013 | ARTICLE
The In-House Psychologist: do we speak the same language?
Objective Interdisciplinary collaboration is gaining importance. Although GP’s have a comprehensive experience in collaboration with psychologists, research on this topic is scarce. In house referrals to a psychologist are assumed to lower the thr...
Auteurs: Birgitte Schoenmakers et Jan De Lepeleire
1 January 2013 | ARTICLE
Hypertensive disorders in pregnancy: a review of international guidelines
International collaboration could facilitate systematic development of guidelines to regulate and improve clinical practice. Insight into existing international guidelines regarding hypertensive disorders in pregnancy (HDP) is essential. Aim was t...
Auteurs: Susanne HE Luitjes, Maurice GAJ Wouters, Tamar Konig, Kees W Hollander, Melanie E van Os, Maurits W van Tulder et Rosella PMG Hermens
1 January 2013 | ARTICLE
Host and environmental predictors of exhaled breath temperature in the elderly
Exhaled breath temperature has been suggested as a new method to detect and monitor pathological processes in the respiratory system. The putative mechanism of this approach is based upon changes in the blood flow. So far potential factors that in...
Auteurs: Esmée Bijnens, Nicky Pieters, Harrie Dewitte, Bianca Cox, Bram G Janssen, Nelly Saenen, Evi Dons, Maurice P Zeegers, Luc Int Panis et Tim Nawrot
Auteurs: Anne-Catherine Vanhove, Wesley Vermaelen, Bart Panis, Rony Swennen et Sebastien Carpentier
Auteurs: Sven Seys, Ann Decraene, Marcin Grabowski, Wim Adriaensen, Ellen Dilissen, Jan Ceuppens, Lieven Dupont et Dominique Bullens
Auteurs: RK Ertmann, JJ Møller, FB Waldorff, V Siersma, S Reventlow et M Söderström