Publicaties

BACKGROUND: Couples with recurrent miscarriage (RM) have an increased risk of one of the partners carrying a structural chromosome abnormality. On the basis of four independent risk factors, an evidence-based model was developed, which allows limi...

UNLABELLED: Patients in the Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly (HORIZON) Recurrent Fracture Trial were assessed for evidence of delayed hip fracture healing. No association was observed between zoledronic acid (...

OBJECTIVE: To study whether the luxury goods make older people feel in better health and whether this association is similar in higher and lower social classes. METHODS: SMILE consists of a Dutch general population consisting of 2.637 men and wome...

BACKGROUND: Point-of-care testing (POCT) is increasingly being used in general practice to assist general practitioners (GPs) in their management of patients with diseases. However, low adherence to quality guidelines in terms of split test proced...

In this study we investigated differences between rescaled generic and CT-based musculoskeletal models. Generic models were rescaled based on gait analysis marker locations. Subject-specific models were constructed by customizing joint kinematics ...

Introduction The most useful CPRs are those that can be applied across multiple settings, have clinical validity and improve patient outcome. In a previous study we systematically identified CPRs to detect serious infection (SI) in acutely ill ch...

BACKGROUND: The Dutch Health Council recently recommended the introduction of a colorectal cancer (CRC) screening programme by faecal occult blood testing (FOBT) for individuals aged 55-75 at population risk of CRC. Individuals at an increased fam...

The umbilical cord is vulnerable to a number of insults which may alter cord morphology, diminish cord flow and ultimately compromise fetal nutrition. Thus, an investigation of the underlying mechanisms of the development of cord morphology and po...

OBJECTIVE: For chronic pain treatment many health care authorities consider morphine to be the reference standard for strategic decisions in pain therapy. Although morphine's effectiveness is clear and its cost is low, it's unclear whether morphin...

IntroductionIn order to improve the quality of care, evidence-based practice seeks to bridge the gap between evidence and practice.While cardiopulmonary resuscitation by laypeople was extensively studied and evidence-based guidelines were publishe...

OBJECTIVE: To collate all available evidence on the diagnostic value of laboratory tests for the diagnosis of serious infections in febrile children in ambulatory settings. DESIGN: Systematic review. DATA SOURCES: Electronic databases, reference t...

Dendritic cells (DC), present in the skin, are the first target cells of dengue virus (DENV). Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) is present on DC and recognizes N-glycosylation sites on the E-...

Methods The BELFRAIL study (BF C80+) is a prospective, observational, population-based cohort study of subjects aged 80 years and older in three well-circumscribed areas in Belgium. The full study design including power calculation has been descri...