Publicaties

UNLABELLED: AIMD: To assess the long-term effectiveness of an integrated disease management (IDM) program (consisting of optimal medication, reactivation, education, and exacerbation management) in primary care patients with chronic obstructive pu...

PURPOSE: For cytostatic agents or when the response assessment is difficult, adaptations to phase II designs may allow a better assessment of therapeutic activity: first by using the progression-free survival rate (PFSR) as primary end-point inste...

STUDY OBJECTIVE: This study reviewed evidence on the effects of nonresuscitative first aid training on competence and helping behavior in laypersons. METHODS: We identified randomized and nonrandomized controlled trials and interrupted time series...

BACKGROUND: There is much evidence for the influence of low socio-economic status on poor health. It is, however, also important to study the ways in which people attain and retain their socio-economic status and the factors that predict changes i...

PURPOSE: We used data from the first large-scale overwhelmingly population-based study (a) to quantify the risk of adverse pregnancy outcomes in survivors of childhood cancer in relation to cancer type and treatment and (b) to assess live birth ra...

Family caregivers of a community-dwelling demented relative experience significant burden in their caregiving role. In particular, behavioural disturbances are expected to be responsible for high caregiver distress and burden. Above, in approximat...

ABSTRACT: OBJECTIVE To evaluate the barriers and facilitators to high quality diabetes care as experienced by General Practitioners (GPs) who participated in an 18-month quality improvement program (QIP). This QIP was implemented to promote compli...

BACKGROUND: The management of patients with head and neck cancer is complex, and implementation of an integrated care program might improve the quality of care. METHODS: A prospective before-after study was performed in 1 clinic for head and neck ...

BACKGROUND: Prompt diagnosis of an acute coronary syndrome is very important and urgent referral to a hospital is imperative because fast treatment can be life-saving and increase the patient's life expectancy and quality of life. The aim of our s...

Background: Increasing numbers of family caregivers are confronted with caring for a demented, community-dwelling relative. Living with, caring for, and supervising a demented older relative places a heavy burden on the involved family members. In...

BACKGROUND: The investigation of rare familial forms of kidney cancer has provided important insights into the biology of sporadic renal cell carcinoma (RCC). In particular, the identification of the von Hippel Lindau (VHL) familial cancer syndrom...

Hip loading affects the development of hip osteoarthritis, bone remodelling and osseointegration of implants. In this study, we analyzed the effect of subject-specific modelling of hip geometry and hip joint centre (HJC) location on the quantifica...

OBJECTIVE: In order to evaluate whether elderly persons with subjective memory complaints may be regarded as a group of potentially vulnerable patients who need close follow-up, we investigated the risk of nursing home placement during a 4-year fo...

BACKGROUND: Adequate information provision is a crucial dimension of high-quality fertility care. Clinical practice guidelines containing consensus-based recommendations may standardize practice between settings. This study was designed for three ...

OBJECTIVE: The aim of the present study was to investigate the differences between characteristics of community dwelling demented and non demented elderly and their caregivers at the moment of definitive institutionalization. METHODS: The study is...

Background. The large majority of people with dementia lives at home, alone or with their partner. Availability, coherence and continuity of formal and informal care providers are necessary conditions for qualitative care. Integration and cooperat...

OBJECTIVES: To investigate whether plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) remains a specific marker of cardiac illness in very old age and can be used to identify very elderly people at high risk for death independent of the p...

Achtergrond: Sinds het invoeren van de Wet van 7 mei 2004 inzake experimenten op de menselijke persoon (WEM) diende geen enkele huisarts een aanvraag in om een geneesmiddelentrial op te starten. Tijdens het uitschrijven van een eigen gerandomiseer...

Objective Caring for a dementia patient has an important negative impact on the general wellbeing of family caregivers. Although highly appreciated by carers, interventions in dementia home care remain mainly ineffective in terms of lowering burde...

BACKGROUND/AIMS: Following lead optimization, a set of substituted imidazopyridines was identified as potent and selective inhibitors of in vitro HCV replication. The particular characteristics of one of the most potent compounds in this series (5...

PURPOSE: To review integrated care interventions and their effects on the quality of care for patients with cancer. DATA SOURCES: Search in Medline and Cochrane Library databases from January 1996 to October 2006. STUDY SELECTION: Randomized contr...

BACKGROUND: Chest pain is an initial symptom for several minor diseases but acute myocardial infarction (AMI) should not be missed. AIM: To assess the influence of initial diagnosis and degree of certainty of this initial diagnosis on the referral...

BACKGROUND AND PURPOSE: : Proton radiation has been used for the treatment of uveal melanoma since 1975, but few studies have been conducted to assess its efficacy and safety. This paper aims to systematically review the effects and side effects o...

Both zygosity and chorionicity provide important information in twin research. The East Flanders Prospective Twin Survey (EFPTS) determines zygosity and chorionicity at birth and therefore provides a gold standard for the testing of diagnostic par...