Publicaties

Een overzicht van alle publicaties van de onderzoekers bij Intego

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1 February 2025 | ARTICLE

Re: Impact of C-reactive protein point-of-care testing on antibiotic prescriptions for children and adults with suspected respiratory tract infections in primary care by Jung et al.

Auteurs: Lars Bjerrum, Ivan Gentile, Oliver van Hecke, Jan Y Verbakel, and Carl Llor

18 January 2025 | ARTICLE

Alcohol, Tobacco and Illicit Drug Use During Pregnancy in the Longitudinal BELpREG Cohort in Belgium Between 2022 and 2024

Auteurs: Sien Lenie, Laure Sillis, Karel Allegaert, Annick Bogaerts, Anne Smits, Kristel Van Calsteren, Jan Verbakel, Veerle Foulon, and Michael Ceulemans

4 January 2025 | ARTICLE

Integrating human biomonitoring exposure data into a primary care morbidity database: a feasibility study

BACKGROUND: The detection of a local per- and polyfluoroalkyl substances (PFAS) pollution hotspot in Zwijndrecht (Belgium) necessitated immediate action to address health concerns of the local community. Several human biomonitoring (HBM) studies w...

Auteurs: Pieter Jansen, Elly Den Hond, Katleen De Brouwere, Endale Alemayehu Ali, Hamid Yimam Hassen, Ilona Gabaret, and Gijs Van Pottelbergh

23 December 2024 | TEXT RESOURCE

Riziv wil dat huisdokters minder maagzuurremmers voorschrijven

Auteurs:

23 December 2024 | ARTICLE

Unravelling the role of health literacy among individuals with multimorbidity: a systematic review and meta-analysis

OBJECTIVE: To examine existing literature regarding health literacy levels and their association with multimorbidity and the potential underlying mechanisms behind the said association. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Th...

Auteurs: Arohi Chauhan, Fernando Gregorio Linares-Jimenez, Girish Chandra Dash, Janine de Zeeuw, Archana Kumawat, Pranab Mahapatra, Andrea F de Winter, Sailesh Mohan, Marjan van den Akker, and Sanghamitra Pati

23 December 2024 | TEXT RESOURCE

Riziv wil dat huisartsen minder maagzuurremmers voorschrijven: "Meer nadelen dan gedacht"

Auteurs:

20 December 2024 | ARTICLE

Benchmarks for low back pain in general practice in Flanders: electronic audit of INTEGO.

BACKGROUND: Low back pain (LBP) is one of the most frequent reasons for encounter in general practice. Yet results from literature show adherence to clinical practice guidelines is low. Audit & feedback is a well-known strategy to improve adher...

Auteurs: Rico Paridaens, Bert Vaes, Steve Van den Bulck, and Justine Soetaert

12 December 2024 | ARTICLE

Associations between subclinical thyroid dysfunction and cardiovascular risk factors according to age and sex.

CONTEXT: Subclinical thyroid dysfunction (ScTD) comprising subclinical hypothyroidism (SHypo) and subclinical hyperthyroidism (SHyper) has been associated with increased risk for cardiovascular events. OBJECTIVE: To assess associations between ScT...

Auteurs: Oliver Baretella, Manuel R Blum, Nazanin Abolhassani, Heba Alwan, Lea Wildisen, Cinzia Del Giovane, Kali Tal, Elisavet Moutzouri, Bjørn O Åsvold, Anne R Cappola, Jacobijn Gussekloo, Massimo Iacoviello, Giorgio Iervasi, Misa Imaizumi, Stefan Weiler, Salman Razvi, José A Sgarbi, Henry Völzke, Suzanne J Brown, John P Walsh, Bert Vaes, Bu B Yeap, Robin PF Dullaart, Stephan JL Bakker, Maryam Kavousi, Graziano Ceresini, Luigi Ferrucci, Drahomir Aujesky, Robin P Peeters, Douglas C Bauer, Martin Feller, and Nicolas Rodondi

6 December 2024 | OTHER

BELpREG, a unique nationwide registry providing novel insights into perinatal medication use and maternal-infant health outcomes in Belgium: implications for internal medicine

Auteurs: Sien Lenie, Laure Sillis, Veerle Foulon, Karel Allegaert, Annick Bogaerts, Maarten De Vos, Titia Hompes, Anne Smits, Kristel Van Calsteren, Jan Verbakel, and Michael Ceulemans

5 December 2024 | ARTICLE

Audit and Feedback Interventions for Antibiotic Prescribing in Primary Care: A Systematic Review and Meta-analysis.

BACKGROUND: This systematic review evaluates the effect of audit and feedback (A&F) interventions targeting antibiotic prescribing in primary care and examines factors that may explain the variation in effectiveness. METHODS: Randomized controlled...

Auteurs: Alice XT Xu, Kevin Brown, Kevin L Schwartz, Soheila Aghlmandi, Sarah Alderson, Jamie Brehaut, Benjamin C Brown, Heiner C Bucher, Janet Clarkson, An De Sutter, Nick A Francis, Jeremy Grimshaw, Ronny Gunnarsson, Michael Hallsworth, Lars Hemkens, Sigurd Høye, Tasneem Khan, Donna Lecky, Felicia Leung, Jeremy Leung, Morten Lindbæk, Jeffrey A Linder, Carl Llor, Paul Little, Denise O'Connor, Céline Pulcini, Kalisha Ramlackhan, Craig R Ramsay, Pär-Daniel Sundvall, Monica Taljaard, Pia Touboul Lundgren, Akke Vellinga, Jan Y Verbakel, Theo J Verheij, Carl Wikberg, and Noah Ivers

1 December 2024 | ARTICLE

Diverse roles of Primary Health Care in COVID-19 vaccination across 28 European countries - Insights from the Eurodata study.

BACKGROUND: The COVID-19 vaccination campaign in several European countries involved collaboration between public health and Primary Health Care (PHC). OBJECTIVE: To highlight the role of PHC professionals in the COVID-19 vaccination rollout, spec...

Auteurs: Marina Guisado-Clavero, Raquel Gómez-Bravo, Ileana Gefaell Larrondo, Lourdes Ramos Del Rio, Louise Fitzgerald, Shlomo Vinker, Bert Vaes, Georgi Tsigarovski, Péter Torzsa, Gunta Ticmane, Theresa Sentker, Alice Serafini, Martin Sattler, Sven Streit, Goranka Petricek, Ferdinando Petrazzuoli, Davorina Petek, Ábel Perjés, Nagu Penakacherla, Oliver Senn, Ana Luisa Neves, Katarzyna Nessler, Liubovė Murauskienė, Jöel Mossong, Liga Kozlovska, Anna Segernäs, Anna Krztoń-Królewiecka, Milena Kostić, Erva Kırkoç Üçüncü, Büsra Çimen Korkmaz, Snežana Knežević, Marijana Jandrić-Kočić, Lisa Kastbom, Ivanna Shushman, Oxana Ilkov, Kathryn Hoffmann, Bruno Heleno, Miroslav Hanževački, Dragan Gjorgjievski, Sabine Feldman, Philippe-Richard Domeyer, Maryher Delphin Peña, Asja Ćosić Divjak, Iliana-Carmen Busneag, Elena Brutskaya-Stempkovskaya, Sherihane Bensemmane, Sabine Bayen, Maria Bakola, Limor Adler, Radost Assenova, Sara Ares-Blanco, María Pilar Astier-Peña, and Heidrun Lingner

1 December 2024 | ARTICLE

Assessment of cardiovascular risk with sulfonylurea use in type 2 diabetes mellitus: A retrospective cohort study.

AIMS: The utilization of sulfonylurea (SU) for the management of Type 2 Diabetes Mellitus (T2DM) has witnessed a decline, attributed to the rising popularity of alternative medications and uncertainties surrounding the cardiovascular risk profi...

Auteurs: Jari Delbaere, Ewoud Deboever, Bert Vaes, Frank Nobels, Pavlos Mamouris, and Geert Goderis

18 November 2024 | ARTICLE

Factors Influencing Outcome After Shoulder Arthroplasty (FINOSA Study): Protocol of a Prospective Longitudinal Study With Randomized Group Allocation.

BACKGROUND: There is an increasing need for evidence-based postoperative rehabilitation strategies to optimize patient outcome. Knowledge of potential prognostic factors could steer the development of rehabilitation protocols and could result in b...

Auteurs: Anke Claes, Annelien De Mesel, Thomas Struyf, Olivier Verborgt, and Filip Struyf

1 November 2024 | ARTICLE

Associations of heat with diseases and specific symptoms in Flanders, Belgium: An 8-year retrospective study of general practitioner registration data

INTRODUCTION: Global temperature rise has become a major health concern. Most previous studies on the impact of heat on morbidity have used hospital data. OBJECTIVE: This study aimed to quantify the association between ambient temperature and a...

Auteurs: Endale Alemayehu Ali, Bianca Cox, Karen Van de Vel, Els Verachtert, Bert Vaes, Simon Gabriel Beerten, Elisa Duarte, Charlotte Scheerens, Raf Aerts, and Gijs Van Pottelbergh

31 October 2024 | ARTICLE

Trends in type 2 diabetes medication use and guideline adherence in Belgian primary care (2019-2023).

AIMS: To assess the prevalence of atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), and chronic kidney disease (CKD) among patients with type 2 diabetes (T2D) in Belgium. To analyze trends in medication use and adherence to gu...

Auteurs: Willem Raat, Pavlos Mamouris, Chantal Mathieu, Geert Goderis, and Bert Vaes

21 October 2024 | ARTICLE

Polypharmacy in Older Patients with Multimorbidity: The Agreement Between Patient and General Practitioner-Reported Drugs Observed in a Pilot cRCT.

Polypharmacy (≥5 drugs) increases the risk of discrepancies between patient- and general practitioner (GP)-reported drugs, leading to adverse outcomes. This explorative analysis assesses the agreement between patient- and GP-reported drugs under t...

Auteurs: Lena Schäfer, Michael Paulitsch, Maria Hanf, Truc Sophia Dinh, Astrid-Alexandra Klein, Sophia Klasing, Hanna Seidling, Karen Voigt, and Marjan van den Akker

10 October 2024 | ARTICLE

Emergence of the B.1.214.2 SARS-CoV-2 lineage with an Omicron-like spike insertion and a unique upper airway immune signature.

We investigate the emergence, mutation profile, and dissemination of SARS-CoV-2 lineage B.1.214.2, first identified in Belgium in January 2021. This variant, featuring a 3-amino acid insertion in the spike protein similar to the Omicron variant, w...

Auteurs: Andrew Holtz, Johan Van Weyenbergh, Samuel L Hong, Lize Cuypers, Áine O'Toole, Gytis Dudas, Marco Gerdol, Barney I Potter, Francine Ntoumi, Claujens Chastel Mfoutou Mapanguy, Bert Vanmechelen, Tony Wawina-Bokalanga, Bram Van Holm, Soraya Maria Menezes, Katja Soubotko, Gijs Van Pottelbergh, Elke Wollants, Pieter Vermeersch, Ann-Sophie Jacob, Brigitte Maes, Dagmar Obbels, Veerle Matheeussen, Geert Martens, Jérémie Gras, Bruno Verhasselt, Wim Laffut, Carl Vael, Truus Goegebuer, Rob van der Kant, Frederic Rousseau, Joost Schymkowitz, Luis Serrano, Javier Delgado, Tom Wenseleers, Vincent Bours, Emmanuel André, Marc A Suchard, Andrew Rambaut, Simon Dellicour, Piet Maes, Keith Durkin, and Guy Baele

9 October 2024 | ARTICLE

DIABEZE: Diabetes self-management among the elderly in a Belgian home for the aged: a best practice implementation project.

OBJECTIVES: The aim of this project was to improve the self-management of diabetes among elderly residents in a Belgian home for the aged. INTRODUCTION: Diabetes is a common chronic condition with significant comorbidity. Incidence is increasing, ...

Auteurs: Marleen Corremans, Comfort Ohenewaa, Isaura Van Steenberghe, Trudy Bekkering, and Hilke Jespers

1 October 2024 | ARTICLE

Sodium-glucose cotransporter-2 (SGLT-2) inhibitors for adults with chronic kidney disease: a clinical practice guideline.

CLINICAL QUESTION: What is the impact of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on survival and on cardiovascular and kidneyoutcomes for adults living with chronic kidney disease (CKD)? CURRENT PRACTICE: Few therapies slow kidney disea...

Auteurs: Arnav Agarwal, Xiaoxi Zeng, Sheyu Li, Daniel Rayner, Farid Foroutan, Bert Aertgeerts, Frederic Coyac, Pauline Darbellay Farhoumand, Andrew Demaine, Anja Fog Heen, Vivekanand Jha, Edward Machuve, Evi Nagler, David J Tunnicliffe, Gordon H Guyatt, Per Olav Vandvik, Belen Ponte, and Thomas Agoritsas

27 September 2024 | OTHER

Clinical prediction models for serious infections in children: external validation in ambulatory care

Background: Distinguishing mild from serious infections (SI) is challenging in children in ambulatory care. Clinical prediction models (CPMs), assisting physicians in clinical decision making, require external validation before clinical use. Aim:...

Auteurs: David Bos, Tine De Burghgraeve, An De Sutter, Frank Buntinx, and Jan Verbakel

22 September 2024 | ARTICLE

Diagnostic accuracy of signs and symptoms in acute coronary syndrome and acute myocardial infarction.

BACKGROUND: Acute coronary syndrome (ACS) and acute myocardial infarction (AMI) account for a large portion of cardiovascular deaths. Signs and symptoms for these syndromes, such as chest pain, are non-specific and can be caused by a variety of no...

Auteurs: Willem Raat, Lotte Nees, and Bert Vaes

20 September 2024 | OTHER

Prevalence of periconceptional use of alcohol in Belgium: insights from the BELpREG pregnancy cohort

Oral Presentation

Auteurs: Sien Lenie, Laure Sillis, veerle Foulon, karel Allegaert, annick Bogaerts, maarten De Vos, titia Hompes, anne Smits, kristel Van Calsteren, Jan Verbakel, and Michael Ceulemans

15 August 2024 | ARTICLE

Development of quality indicators for hypertension, extractable from the electronic health record of the general practitioner: a rand-modified Delphi method

Auteurs: Katrien Danhieux, Marieke Hollevoet, Sien Lismont, Pieter Taveirne, Lotte Van Vaerenbergh, Bert Vaes, and Steve van den Bulck

8 August 2024 | ARTICLE

Effectiveness of safety netting approaches for acutely ill children: a network meta-analysis.

BACKGROUND: Safety netting advice (SNA) can help in the management of acutely ill children. AIM: Assess the effectiveness of different SNA methods for acutely ill children on antibiotic prescription and consumption. DESIGN AND SETTING: Systematic ...

Auteurs: Ruben Burvenich, David Ag Bos, Lien Lowie, Kiyano Peeters, Jaan Toelen, Laure Wynants, and Jan Y Verbakel

8 August 2024 | ARTICLE

Physicians' and residents' educational needs regarding shared decision making: A focus group study.

OBJECTIVES: To explore the educational needs of physicians and residents regarding shared decision making (SDM). METHODS: We conducted eight focus groups with 12 general practitioners (GPs), 14 hospital specialists, 12 hospital specialist resident...

Auteurs: Pieter Van Bostraeten, Jasmien Jaeken, Nathan Reyn, Laura Van Mileghem, Lien Mertens, Ann Deketelaere, Geertruida Bekkering, Bert Aertgeerts, Mieke Vermandere, and Nicolas Delvaux

1 August 2024 | ARTICLE

Knowledge and prescribing behaviour of Flemish general practitioners regarding novel glucose-lowering medications: Online cross-sectional survey.

AIMS: To determine the knowledge and prescribing behaviour regarding new type 2 diabetes medication in general practice. Physicians in Belgium are bound by the prescription criteria which do not always correspond to the international guidelines. D...

Auteurs: Julie Lecomte, Isabelle Op de Beeck, Pavlos Mamouris, Chantal Mathieu, and Geert Goderis

30 July 2024 | ARTICLE

Transforming healthcare: A pilot study to improve primary healthcare professionals' self-management support behaviour through blended learning.

BACKGROUND: Self-management of a chronic condition is a complex but increasingly important issue. However, a supportive attitude and behaviour among healthcare professionals is hampered by a lack of awareness, knowledge and motivation. In addition...

Auteurs: Lotte Timmermans, Peter Decat, Veerle Foulon, Ann Van Hecke, Mieke Vermandere, Birgitte Schoenmakers, and Primary Care Academy

16 July 2024 | ARTICLE

The Use of COVID-19 Mobile Apps in Connecting Patients with Primary Healthcare in 30 Countries: Eurodata Study.

BACKGROUND: The COVID-19 pandemic has necessitated changes in European healthcare systems, with a significant proportion of COVID-19 cases being managed on an outpatient basis in primary healthcare (PHC). To alleviate the burden on healthcare faci...

Auteurs: Raquel Gómez-Bravo, Sara Ares-Blanco, Ileana Gefaell Larrondo, Lourdes Ramos Del Rio, Limor Adler, Radost Assenova, Maria Bakola, Sabine Bayen, Elena Brutskaya-Stempkovskaya, Iliana-Carmen Busneag, Asja Ćosić Divjak, Maryher Delphin Peña, Philippe-Richard Domeyer, Sabine Feldmane, Louise Fitzgerald, Dragan Gjorgjievski, Mila Gómez-Johansson, Miroslav Hanževački, Oksana Ilkov, Shushman Ivanna, Marijana Jandrić-Kočić, Vasilis Trifon Karathanos, Erva Ücüncü, Aleksandar Kirkovski, Snežana Knežević, Büsra Çimen Korkmaz, Milena Kostić, Anna Krztoń-Królewiecka, Liga Kozlovska, Heidrun Lingner, Liubovė Murauskienė, Katarzyna Nessler, Naldy Parodi López, Ábel Perjés, Davorina Petek, Ferdinando Petrazzuoli, Goranka Petricek, Martin Sattler, Bohumil Seifert, Alice Serafini, Theresa Sentker, Gunta Ticmane, Paula Tiili, Péter Torzsa, Kirsi Valtonen, Bert Vaes, Shlomo Vinker, Ana Luisa Neves, Marina Guisado-Clavero, María Pilar Astier-Peña, and Kathryn Hoffmann

26 June 2024 | OTHER

Tackling methodological barriers: a journey of creating an accessible healthcare survey for a diverse population

Auteurs: Sinem Bilican, Antoon Cox, Olivier Hoogmartens, Mohamed Irfan, Marc Sabbe, Heidi Salaets, and Birgitte Schoenmakers

26 June 2024 | ARTICLE

Mapping implementation strategies to reach community-dwelling older adults in Northwest Switzerland

BACKGROUND: In Northwestern Switzerland, recent legislation tackles the needs of community-dwelling older adults by creating Information and Advice Centers (IACs). IACs are a new service in the community that aims to assess the needs and provide i...

Auteurs: Maria Jose Mendieta, Geert Goderis, Andreas Zeller, Olivia Yip, Flaka Siqeca, Franziska Zuniga, Leah L Zullig, Sabina M De Geest, Mieke Deschodt, Johan Flamaing, and Suzanne Dhaini