Auteurs:Laure Sillis, Veerle Foulon, Karel Allegaert, Annick Bogaerts, Maarten De Vos, Titia Hompes, Anne Smits, Kristel Van Calsteren, Jan Verbakel, and Michael Ceulemans
BACKGROUND: IgG anti-spike (S) antibodies arise after SARS-CoV-2 infection as well as vaccination. Levels of IgG anti-S are linked to neutralizing antibody titers and protection against (re)infection. METHODS: We measured IgG anti-S and surrogate ...
Auteurs:Bram Decru, Jan Van Elslande, Sophie Steels, Gijs Van Pottelbergh, Lode Godderis, Bram Van Holm, Xavier Bossuyt, Johan Van Weyenbergh, Piet Maes, and Pieter Vermeersch
BACKGROUND: To evaluate clinical characteristics, imaging findings, therapeutic approach and outcome of paediatric patients with Chronic Non-Bacterial Osteomyelitis (CNO). METHODS: Retrospective review of 30 children diagnosed with CNO at two tert...
Auteurs:Sara Kaut, Ine Van den Wyngaert, Davy Christiaens, Carine Wouters, Nathalie Noppe, Nele Herregods, Joke Dehoorne, and Lien De Somer
BACKGROUND: Recognising patients who need immediate hospital treatment for sepsis while simultaneously limiting unnecessary referrals is challenging for GPs. AIM: To develop and validate a sepsis prediction model for adult patients in primary care...
Auteurs:Feike J Loots, Marleen Smits, Rogier M Hopstaken, Kevin Jenniskens, Fleur H Schroeten, Ann van den Bruel, Alma C van de Pol, Jan Jelrik Oosterheert, Hjalmar Bouma, Paul Little, Michael Moore, Sanne van Delft, Douwe Rijpsma, Joris Holkenborg, Bas CT van Bussel, Ralph Laven, Dennis CJJ Bergmans, Jacobien J Hoogerwerf, Gideon HP Latten, Eefje GPM de Bont, Paul Giesen, Annemarie den Harder, Ron Kusters, Arthur RH van Zanten, and Theo JM Verheij
In 2021, the World Health Organization issued a call to action to defeat meningitis by 2030. Neisseria meningitidis is a major cause of meningitis and septicaemia. Invasive meningococcal disease (IMD) is a severe and life-threatening disease but a...
Auteurs:David Tuerlinckx, Marc Raes, Marek Wojciechowski, Wesley Mattheus, Laurence Derycker, Kathleen Billiaert, Jean-Michel Heine, and Jan Verbakel
BACKGROUND AND AIMS: Screening and brief interventions (SBI) in primary health-care practices (PHCP) are effective in reducing reported alcohol consumption, but have not been routinely implemented. Most programs seeking to improve implementation r...
Auteurs:Frederico Rosario, Milica Vasiljevic, Leo Pas, Colin Angus, Cristina Ribeiro, and Niamh Fitzgerald
Polypharmacy is associated with a risk of negative health outcomes. Potentially inappropriate medications, interactions resulting from contradicting medical guidelines, and inappropriate monitoring, all increase the risk. This process evaluation (...
Auteurs:Robin Bruenn, Dorothea Lemke, Jale Basten, Petra Kellermann-Muehlhoff, Juliane Koeberlein-Neu, Christiane Muth, and Marjan van den Akker
Specific burdens of older spousal caregivers often remain invisible, and spousal caregivers rarely receive the support they need to perform their role. To provide suitable support for spousal caregivers, it is crucial to develop a comprehensive un...
Auteurs:Sanne Peters, Elien Van Hout, Leontien Jansen, and Marjan van den Akker
BACKGROUND: Diagnosing childhood urinary tract infections (UTIs) is challenging. Clinical prediction rules may help to identify children that require urine sampling. However, there is a lack of research to determine the accuracy of the scores in g...
Auteurs:Hanne Ann Boon, Jan Y Verbakel, Tine De Burghgraeve, and Ann Van den Bruel
CLINICAL QUESTION: In adults with low density lipoprotein (LDL) cholesterol levels >1.8 mmol/L (>70 mg/dL) who are already taking the maximum dose of statins or are intolerant to statins, should another lipid-lowering drug be added, either a propr...
Auteurs:Qiukui Hao, Bert Aertgeerts, Gordon Guyatt, Geertruida E Bekkering, Per Olav Vandvik, Safi U Khan, Nicolas Rodondi, Jackson Rod, Jean-Luc Reny, Lubna Al Ansary, Mieke Van Driel, Willem JJ Assendelft, Thomas Agoritsas, Frederick Spencer, Reed AC Siemieniuk, Lyubov Lytvyn, Anja Fog Heen, Qian Zhao, Irbaz Bin Riaz, Dirk Ramaekers, Patrick Mba Okwen, Ye Zhu, Annabel Dawson, Mersa Caius Ovidiu, Willy Vanbrabant, Sheyu Li, and Nicolas Delvaux
OBJECTIVE: The aim of this scoping review was to investigate the published literature on written assessment of communication skills in health professionals' education. METHODS: Pubmed, Embase, Cinahl and Psychnfo were screened for the period 1/199...
Auteurs:Noelle Junod Perron, Peter Pype, Marc van Nuland, Maria Magdalena Bujnowska-Fedak, Marcela Dohms, Geurt Essers, Ragnar Joakimsen, Zoi Tsimtsiou, and Claudia Kiessling
OBJECTIVES: The aim of this study was to develop a model that can discriminate between different etiologies of abnormal uterine bleeding. DESIGN: The International Endometrial Tumor Analysis 1 study is a multicenter observational diagnostic study ...
Auteurs:Laure Wynants, Jan Yvan Jos Verbakel, Lil Valentin, Bavo De Cock, M Angela Pascual, Francesco PG Leone, Povilas Sladkevicius, Ruben Heremans, Juan Luis Alcazar, Angelo Votino, Robert Fruscio, Elisabeth Epstein, Tom Bourne, Ben Van Calster, Dirk Timmerman, and Thierry Van den Bosch
UNLABELLED: Acute kidney injury (AKI) occurs frequently after cardiac surgery in children. Although current diagnostic criteria rely on serum creatinine and urine output, changes occur only after considerable loss of kidney function. This meta-ana...
Auteurs:Jef Van den Eynde, Art Schuermans, Jan Y Verbakel, Marc Gewillig, Shelby Kutty, Karel Allegaert, and Djalila Mekahli
OBJECTIVE: This study will synthesize the available evidence on the prevalence and incidence of chemotherapy-induced taste alterations in adult cancer patients. INTRODUCTION: Taste and smell alterations in cancer patients due to chemotherapy affec...
Auteurs:Marleen Corremans, Dimitri Mortelmans, Bart Geurden, Sarah Luyten, and Geertruida Bekkering
We retrospectively compared the long-term evolution of IgG anti-spike (S) and anti-nucleocapsid (N) levels (Abbott immunoassays) in 116 non-severe and 115 severe SARS-CoV-2 infected patients from 2 university hospitals up to 365 days post positive...
Auteurs:Jan Van Elslande, Matthijs Oyaert, Natalie Lorent, Yannick Vande Weygaerde, Gijs Van Pottelbergh, Lode Godderis, Marc Van Ranst, Emmanuel Andre, Elizaveta Padalko, Katrien Lagrou, Stien Vandendriessche, and Pieter Vermeersch
Auteurs:Anissa All, Mieke Embo, Oona Janssens, Marieke Robbrecht, Sofie Van Ostaeyen, Vasiliki Andreou, Hilde De Grave, Lieven De Marez, Helena Demey, Leen Harens, Alice Muhayimana, Donatilla Mukamana, Josephine Murekezi, Jean Pierre Ndayisenga, Koen Norga, Tammy Schellens, Olive Tengera, and Martin Valcke
OBJECTIVE: To compare the impact of ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on cardiovascular outcomes in adults taking maximally tolerated statin therapy or who are statin intolerant. DESIGN: Network meta-an...
Auteurs:Safi U Khan, Siva H Yedlapati, Ahmad N Lone, Qiukui Hao, Gordon Guyatt, Nicolas Delvaux, Geertruida E Trudy Bekkering, Per Olav Vandvik, Irbaz Bin Riaz, Sheyu Li, Bert Aertgeerts, and Nicolas Rodondi
BACKGROUND AND AIMS: Wastewater-based epidemiology (WBE) is a complementary epidemiological data source to monitor stimulant consumption. The aims were to: (i) study intra- and inter-year temporal changes in stimulant use in Belgium during the fir...
Auteurs:Tim Boogaerts, Maarten Quireyns, Maarten De Prins, Bram Pussig, Hans De Loof, Catharina Matheï, Bert Aertgeerts, Virginie Van Coppenolle, Erik Fransen, Adrian Covaci, and Alexander LN Van Nuijs
Although marketing authorisation holders (MAHs) are involved in monitoring medication safety, it was unclear how they experience their role and current monitoring activities in pregnancy. Therefore, a qualitative study using online focus groups wi...
Auteurs:Laure Sillis, Veerle Foulon, Jan Verbakel, and Michael Ceulemans
Background Adverse drug events following inappropriate prescribing in the hospital cause a substantial and avoidable medical and economic burden to hospitals, payers and patients alike. A clinical rule-based, pharmacist-led medication-review servi...
Auteurs:Erinn D'hulster, Charlotte Quintens, Raf Bisschops, Rik Willems, Willy E Peetermans, Jan Y Verbakel, and Jeroen Luyten
Context: Primary aldosteronism (PA) is a common form of hypertension caused by excess production of the adrenal hormone aldosterone. Screening hypertensive patients with a simple blood test enables early detection and targeted treatment of PA, lea...
Auteurs:Abhir Nainani, Grant Russell, Jun Yang, and Sanne Peters
INTRODUCTION: Older patients with multimorbidity, polypharmacy and related complex care needs represent a growing proportion of the population and a challenge for healthcare systems. Particularly in transitional care (hospital admission and hospit...
Auteurs:Maria-Sophie Brueckle, Truc Sophia Dinh, Astrid-Alexandra Klein, Lisa Rietschel, Jenny Petermann, Franziska Brosse, Sylvia Schulz-Rothe, Ana Isabel Gonzalez-Gonzalez, Martin Kramer, Jennifer Engler, Karola Mergenthal, Christiane Muth, Karen Voigt, and Marjan van den Akker
We report IgG anti-spike levels up to 3 months after vaccination with 2 doses of BNT162b2 mRNA vaccine in healthcare workers (HCW). The antibody response was significantly stronger in previously infected vaccinated HCW compared to uninfected HCW, ...
Auteurs:Jan Van Elslande, Matthias Weemaes, Lode Godderis, Gijs Van Pottelbergh, Xavier Bossuyt, and Pieter Vermeersch
In Belgium, nursing home staff (NHS) and residents were prioritised for COVID-19 vaccination. However, vaccine hesitancy may have impacted vaccination rates. In this study, a random stratified sample of NHS (N = 1142), vaccinated and unvaccinated,...
Auteurs:Marina Digregorio, Pauline Van Ngoc, Simon Delogne, Eline Meyers, Ellen Deschepper, Els Duysburgh, Liselore De Rop, Tine De Burghgraeve, Anja Coen, Nele De Clercq, An De Sutter, Jan Y Verbakel, Piet Cools, Stefan Heytens, Laetitia Buret, and Beatrice Scholtes
