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1 January 2020 | ARTICLE

Abstracts book.

Auteurs: Patrick Van De Voorde

1 January 2020 | ARTICLE

Routine laboratory testing to determine if a patient has COVID-19

BACKGROUND: Specific diagnostic tests to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and resulting COVID-19 disease are not always available and take time to obtain results. Routine laboratory markers such as white blood ce...

Auteurs: Inge Stegeman, Eleanor A Ochodo, Fatuma Guleid, Gea A Holtman, Bada Yang, Clare Davenport, Jonathan J Deeks, Jacqueline Dinnes, Sabine Dittrich, Devy Emperador, Lotty Hooft, Rene Spijker, Yemisi Takwoingi, Ann Van den Bruel, Junfeng Wang, Miranda Langendam, Jan Y Verbakel, and Mariska MG Leeflang

1 January 2020 | ARTICLE

Best Evidence Topic Report: Welke klinische tekens kunnen artsen ondersteunen in hun beslissing om COVID-19 positieve patiënten al dan niet te laten opnemen in het ziekenhuis?

Auteurs: AS Wouters, K Wierinck, G Lenaerts, J Verbakel, J De Lepeleire, and B Schoenmakers

1 January 2020 | ARTICLE

The epidemiology of knee osteoarthritis in general practice: a registry-based study

OBJECTIVES: The present study investigated (1) trends in the prevalence and incidence of knee osteoarthritis over a 20-year period (1996-2015); (2) trends in multimorbidity and (3) trends in drug prescriptions. DESIGN: Registry-based study. SET...

Auteurs: David Spitaels, Pavlos Mamouris, Bert Vaes, Miek Smeets, Frank Luyten, Rosella Hermens, and Patrick Vankrunkelsven

1 January 2020 | ARTICLE

Best Evidence Topic Report: Moet het gebruik van NSAID's bij een Covid-19 positieve patiënt vermeden worden?

Auteurs: L Aerts, J Anthonissen, G Lenaerts, and J Verbakel

1 January 2020 | ARTICLE

Best Evidence Topic Report: Heeft telefonische triage door een niet-arts een effect op de werkdruk voor artsen en tevredenheid bij patënten tijdens een pandemie?

Auteurs: L Breughe, K Callens, T Bekkering, and J Verbakel

1 January 2020 | ARTICLE

Best Evidence Topic Report: Wat is het mortaliteitspercentage bij bevestigde COVID-19 patiënten?

Auteurs: T Germeys, M Groffi, T Bekkering, J Verbakel, and N Delvaux

1 January 2020 | ARTICLE

Best Evidence Topic Report: Zijn zelfgemaakte maskers effectief ter preventie van virustransmissie bij COVID-19?

Auteurs: F Leirman, N Koster, G Lenaerts, J Verbakel, and N Delvaux

1 January 2020 | ARTICLE

Best Evidence Topic Report: Wat is het nut van een stethoscoop ontsmetten ter preventie van overdracht virale infecties (in het bijzonder SARS-CoV-2)?

Auteurs: L Ceulemans, O Claes, T Bekkering, J Verbakel, and P Vankrunkelsven

1 January 2020 | ARTICLE

Best Evidence Topic Report: Welke patiëntengroepen lopen een hoger risico op complicaties veroorzaakt door COVID-19?

Auteurs: W De Mol, M Galouchka, T Bekkering, J Verbakel, and M Vermandere

1 January 2020 | ARTICLE

Best Evidence Topic Report: Kan het gebruik van een mondmasker helpen tegen de verspreiding van COVID-19 infectie?

Auteurs: M Himpens, N Kerkhof, G Lenaerts, J Verbakel, and M Vermandere

1 January 2020 | ARTICLE

Best Evidence Topic Report: Wat is de meerwaarde van antibiotica voor het vermijden van hospitalisatie bij patiënten met een COVID-19 infectie? Wanneer opstarten?

Auteurs: I Lutz, D Mannens, T Bekkering, J Verbakel, and B Vaes

1 January 2020 | ARTICLE

Best Evidence Topic Report: Dient men groepen te beperkten tot 5 personen om het risico op COVID-19 infectie te verlagen?

Auteurs: L Philipsen, R Packet, G Lenaerts, J Verbakel, and B Schoenmakers

1 January 2020 | ARTICLE

Best Evidence Topic Report: Geeft medische beeldvorming extra informatie over COVID-19 pneumonie en kan dit gebruikt worden in de eerste lijn?

Auteurs: R Vandenberghe, M Vandoorne, T Bekkering, J Verbakel, and P Vankrunkelsven

1 January 2020 | ARTICLE

Best Evidence Topic Report: Heeft het zin contact met gezonde kinderen te vermijden om sars-CoV-2 virustransmissie te voorkomen?

Auteurs: E Vingerhoets, V Wauteraerts, G Lenaerts, J Verbakel, and M Van Nuland

1 January 2020 | ARTICLE

Advancing cross-national planning and partnership: Proceedings from the International Multimorbidity Symposium 2019.

The International Multimorbidity Symposium was held in November 2019 at Western University to achieve three main objectives: to discuss progress and findings from various jurisdictions; to facilitate collaboration through group discussion to ident...

Auteurs: Kathryn Nicholson, Tine De Burghgraeve, Martin Fortin, Lauren E Griffith, Silvan Licher, Daniel Lizotte, Frances S Mair, Ruben Miozzo, Maede Sadat Nouri, Bridget L Ryan, Eng Sing Lee, Susan Smith, Moira Stewart, Amanda L Terry, Mayra Tisminetzky, Maria Ukhanova, Stephen Wetmore, and Saverio Stranges

1 January 2020 | ARTICLE

Development of a clinical prediction rule for sepsis in primary care: protocol for the TeSD-IT study.

Background: Early recognition and treatment of sepsis is crucial to prevent detrimental outcomes. General practitioners (GPs) are often the first healthcare providers to encounter seriously ill patients. The aim of this study is to assess the valu...

Auteurs: Feike J Loots, Rogier Hopstaken, Kevin Jenniskens, Geert WJ Frederix, Alma C van de Pol, Ann Van den Bruel, Jan Jelrik Oosterheert, Arthur RH van Zanten, Marleen Smits, and Theo JM Verheij

1 January 2020 | ARTICLE

End-of-life care preferences of older patients with multimorbidity: protocol of a mixed-methods systematic review

INTRODUCTION: End-of-life care is an essential task performed by most healthcare providers and often involves decision-making about how and where patients want to receive care. To provide decision support to healthcare professionals and patients i...

Auteurs: Ana Isabel Gonzalez-Gonzalez, Christine Schmucker, Julia Nothacker, Truc Sophia Nguyen, Maria-Sophie Brueckle, Jeanet Blom, Marjan van den Akker, Kristian Roettger, Odette Wegwarth, Tammy Hoffmann, Ferdinand M Gerlach, Sharon E Straus, Joerg J Meerpohl, and Christiane Muth

1 January 2020 | ARTICLE

Thoracic imaging tests for the diagnosis of COVID-19

BACKGROUND: The diagnosis of infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents major challenges. Reverse transcriptase polymerase chain reaction (RT-PCR) testing is used to diagnose a current infection, but its...

Auteurs: Jean-Paul Salameh, Mariska MG Leeflang, Lotty Hoo, Nayaar Islam, Trevor A McGrath, Christian B van der Pol, Robert A Frank, Ross Prager, Samanjit S Hare, Carole Dennie, Rene Spijker, Jonathan J Deeks, Jacqueline Dinnes, Kevin Jenniskens, Daniel A Korevaar, Jeremie F Cohen, Ann Van den Bruel, Yemisi Takwoingi, Janneke van de Wijgert, Johanna AAG Damen, Junfeng Wang, and Matthew DF McInnes

1 January 2020 | ARTICLE

Differential Impact of Cognitive Impairment in MCI Patients: A Case-Based Report

Mild cognitive impairment (MCI) traditionally refers to an intermediate stage between healthy individuals and early Alzheimer disease. Evidence shows grey and white matter volume changes and decrease in several executive functions, albeit the rela...

Auteurs: Valentina Pergher, Birgitte Schoenmakers, Philippe Demaerel, Jos Tournoy, and Marc M Van Hulle

1 January 2020 | ARTICLE

Exploring the appropriateness of antibiotic prescribing for common respiratory tract infections in UK primary care

OBJECTIVES: To use illness severity scores to evaluate the appropriateness of antibiotic prescribing in UK general practice. METHODS: We describe variations in practice prescribing rates, taking account of illness severity. We used three scores in...

Auteurs: Beth Stuart, Hannah Brotherwood, Catherine Van't Hoff, Alastair Brown, Ann van den Bruel, Alastair D Hay, Michael Moore, and Paul Little

1 January 2020 | ARTICLE

Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19 disease

BACKGROUND: Some people with SARS-CoV-2 infection remain asymptomatic, whilst in others the infection can cause mild to moderate COVID-19 disease and COVID-19 pneumonia, leading some patients to require intensive care support and, in some cases, t...

Auteurs: Thomas Struyf, Jonathan J Deeks, Jacqueline Dinnes, Yemisi Takwoingi, Clare Davenport, Mariska MG Leeflang, Rene Spijker, Lotty Hooft, Devy Emperador, Sabine Dittrich, Julie Domen, Sebastiaan RA Horn, and Ann Van den Bruel

1 January 2020 | ARTICLE

Antibody tests for identification of current and past infection with SARS-CoV-2

BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and resulting COVID-19 pandemic present important diagnostic challenges. Several diagnostic strategies are available to identify current infection, rule out infecti...

Auteurs: Jonathan J Deeks, Jacqueline Dinnes, Yemisi Takwoingil, Clare Davenport, Ren Spijker, Sian Taylor-Phillips, Ada Adrianol, Sophie Beesel, Janine Dretzkel, Lavinia Ferrante di Ruffanol, Isobel M Harris, Malcolm J Price, Sabine Dittrich, Devy Emperador, Lotty Hooft, Mariska MG Leeflang, and Ann Van den Bruel

1 January 2020 | ARTICLE

Clinical Reliability of point-of-care tests to support community based acute ambulatory care.

OBJECTIVE: To ensure clinicians can rely on point-of-care testing results, we assessed agreement between point-of-care tests for creatinine, urea, sodium, potassium, calcium, Hb, INR, CRP and subsequent corresponding laboratory tests. PARTICIPANTS...

Auteurs: JY Verbakel, C Richardson, T Elias, J Bowen, R Hassanzadeh, B Shine, I Smith, G Hayward, A Van den Bruel, ST Pendlebury, and D Lasserson

1 January 2020 | ARTICLE

Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection (Review)

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting COVID-19 pandemic present important diagnostic challenges. Several diagnostic strategies are available to identify or rule out current infection, identify p...

Auteurs: Jacqueline Dinnes, Jonathan J Deeks, Ada Adriano, Sarah Berhane, Clare Davenport, Sabine Dittrich, Devy Emperador, Yemisi Takwoingi, Jane Cunningham, Sophie Beese, Janine Dretzke, Lavinia Ferrante di Ruffano, Isobel M Harris, Malcolm J Price, Sian Taylor-Phillips, Lotty Hooft, Mariska MG Leeflang, Rene Spijker, and Ann Van den Bruel

1 January 2020 | ARTICLE

Best Evidence Topic Report: Welke respiratoire bescherming voorziet men bij contact met patiënten die mogelijks besmet zijn met het SARS-Cov2 virus?

Auteurs: E Blanpain, J Berben, G Lenaerts, J Verbakel, and B Aertgeerts

1 January 2020 | ARTICLE

Editorial TvGG best BETs

Auteurs: J Verbakel, J De Lepeleire, and B Aertgeerts

1 January 2020 | ARTICLE

Biomarkers versus traditional risk factors to predict cardiovascular events in very old adults: cross-validated prospective cohort study

OBJECTIVES: To test new cardiovascular (CV) risk models in very old adults with and without a history of CV disease (CVD), based on traditional risk factors and biomarkers. DESIGN: Cross-validated prospective cohort study. The models were tested i...

Auteurs: Bert Vaes, Paulien Indestege, Tinne Serneels, Eralda Hegendorfer, Petra G van Peet, Rosalinde KE Poortvliet, Pierre Wallemacq, Jacobijn Gussekloo, and Jan Degryse

1 January 2020 | ARTICLE

Validation of replacement questions for slowness and weakness to assess the Fried Phenotype: a cross-sectional study

PURPOSE: When screening large populations, performance-based measures can be difficult to conduct because they are time consuming and costly, and require well-trained assessors. The aim of the present study is to validate a set of questions replac...

Auteurs: Michaël Christiaan John Van der Elst, Birgitte Schoenmakers, Linda PM Op het Veld, Ellen E De Roeck, Anne van der Vorst, Jos MGA Schols, Jan De Lepeleire, and Gertrudis IJM Kempen

1 January 2020 | ARTICLE

Best Evidence Topic Report: Welke parameters worden best opgevolgd bij het monitoren van patiënten met een matig ernstige Covid-19 infectie?

Auteurs: L Michielsen, C Merckx, T Bekkering, J Verbakel, and M Van Nuland