Publicaties

Een overzicht van alle publicaties van de onderzoekers bij Intego

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1 April 2019 | OTHER

Reaching out to the undiagnosed people with hepatitis C infection in Belgium: A pilot study

Auteurs: Dana Busschots, Rob Bielen, Ozgur Koc, Eefje Dercon, Tessa Windelinckx, Griet Maertens, Stefan Bourgeois, Catharina Mathei, and Geert Robaeys

1 April 2019 | ARTICLE

Polyunsaturated fatty acid status at birth, childhood growth, and cardiometabolic risk: a pooled analysis of the MEFAB and RHEA cohorts

BACKGROUND/OBJECTIVES: Polyunsaturated fatty acid (PUFA) status during pregnancy has been suggested to influence offspring obesity and cardiometabolic health. We assessed whether prenatal PUFA exposure is associated with rapid infant growth, child...

Auteurs: Nikos Stratakis, Marij Gielen, Katerina Margetaki, Renate HM de Groot, Maria Apostolaki, Georgia Chalkiadaki, Marina Vafeiadi, Vasiliki Leventakou, Marianna Karachaliou, Roger W Godschalk, Manolis Kogevinas, Euripides G Stephanou, Maurice P Zeegers, and Leda Chatzi

1 April 2019 | OTHER

Availability of information in drug labels for appropriate prescribing in patients with hepatic impairment

Auteurs: Rianne A Weersink, Lotte Timmermans, Margje H Monster-Simons, Peter GM Mol, Herold J Metselaar, Sander D Borgsteede, and Katja Taxis

1 April 2019 | ARTICLE

The diagnostic performance of current tumour markers in surveillance for recurrent testicular cancer: A diagnostic test accuracy systematic review

In this diagnostic test accuracy systematic review we summarise the evidence on the diagnostic accuracy of blood α-fetoprotein (AFP), human chorionic gonadotropin (HCG) and lactate dehydrogenase (LDH) in surveillance for testicular cancer recurren...

Auteurs: Brian D Nicholson, Nicholas R Jones, Andrew Protheroe, Johnson Joseph, Nia W Roberts, Ann Van den Bruel, and Thomas R Fanshawe

1 April 2019 | ARTICLE

Implementing alcohol screening and brief interventions in primary health care: study protocol for a pilot cluster randomized controlled trial

BACKGROUND: Alcohol is one of the most important risk factors contributing to the global burden of disease. Screening and brief interventions in primary care settings are effective in reducing alcohol consumption. However, implementation of such i...

Auteurs: Frederico Rosario, Milica Vasiljevic, Leo Pas, Niamh Fitzgerald, and Cristina Ribeiro

1 April 2019 | OTHER

Behavioural changes, sharing behaviour and psychological responses after receiving direct-to-consumer genetic test results:a systematic review and meta-analysis (vol 9, pg 1, 2019)

The published online version contains mistake in the Abstract section. The percentages for 'any positive lifestyle change' and 'improved dietary practices' have unintentionally been incorrectly reported.

Auteurs: Kelly FJ Stewart, Anke Wesselius, Maartje AC Schreurs, Annemie MWJ Schols, and Maurice P Zeegers

1 April 2019 | ARTICLE

Low thyroid function is not associated with an accelerated deterioration in renal function

BACKGROUND: Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hormone al...

Auteurs: Christiaan L Meuwese, Merel van Diepen, Anne R Cappola, Mark J Sarnak, Michael G Shlipak, Douglas C Bauer, Linda P Fried, Massimo Iacoviello, Bert Vaes, Jean Degryse, Kay-Tee Khaw, Robert N Luben, Bjorn O Asvold, Trine Bjoro, Lars J Vatten, Anton JM de Craen, Stella Trompet, Giorgio Iervasi, Sabrina Molinaro, Graziano Ceresini, Luigi Ferrucci, Robin PF Dullaart, Stephan JL Bakker, J Wouter Jukema, Patricia M Kearney, David J Stott, Robin P Peeters, Oscar H Franco, Henry Volzke, John P Walsh, Alexandra Bremner, Jose A Sgarbi, Rui MB Maciel, Misa Imaizumi, Waka Ohishi, Friedo W Dekker, Nicolas Rodondi, Jacobijn Gussekloo, and Wendy PJ den Elzen

28 March 2019 | ARTICLE

Prevalence of multidrug-resistant organisms in nursing homes in Belgium in 2015

OBJECTIVES: Following two studies conducted in 2005 and 2011, a third prevalence survey of multidrug-resistant microorganisms (MDRO) was organised in Belgian nursing homes (NHs) using a similar methodology. The aim was to measure the prevalence of...

Auteurs: Katrien Latour, Te-Din Huang, Beatrice Jans, Catherine Berhin, Pierre Bogaerts, Audrey Noel, Claire Nonhoff, Magali Dodemont, Olivier Denis, Margareta Ieven, Katherine Loens, Didier Schoevaerdts, Boudewijn Catry, and Youri Glupczynski

27 March 2019 | ARTICLE

Mobile Phone-Based Use of the Photoplethysmography Technique to Detect Atrial Fibrillation in Primary Care: Diagnostic Accuracy Study of the FibriCheck App

BACKGROUND: Mobile phone apps using photoplethysmography (PPG) technology through their built-in camera are becoming an attractive alternative for atrial fibrillation (AF) screening because of their low cost, convenience, and broad accessibility. ...

Auteurs: Tine Proesmans, Christophe Mortelmans, Ruth Van Haelst, Frederik Verbrugge, Pieter Vandervoort, and Bert Vaes

1 March 2019 | ARTICLE

Risk of complications in patients with conservatively managed ovarian tumours (IOTA5): a 2-year interim analysis of a multicentre, prospective, cohort study

BACKGROUND: Ovarian tumours are usually surgically removed because of the presumed risk of complications. Few large prospective studies on long-term follow-up of adnexal masses exist. We aimed to estimate the cumulative incidence of cyst complicat...

Auteurs: Wouter Froyman, Chiara Landolfo, Bavo De Cock, Laure Wynants, Povilas Sladkevicius, Antonia Carla Testa, Caroline Van Holsbeke, Ekaterini Domali, Robert Fruscio, Elisabeth Epstein, Maria Jose dos Santos Bernardo, Dorella Franchi, Marek Jerzy Kudla, Valentina Chiappa, Juan Luis Alcazar, Francesco Paolo Giuseppe Leone, Francesca Buonomo, Lauri Hochberg, Maria Elisabetta Coccia, Stefano Guerriero, Nandita Deo, Ligita Jokubkiene, Jeroen Kayser, An Coosemans, Ignace Vergote, Jan Yvan Verbakel, Tom Bourne, Ben Van Calster, Lil Valentin, and Dirk Timmerman

1 March 2019 | ARTICLE

Educational outreach visits to improve knee osteoarthritis management in primary care

BACKGROUND: Knee osteoarthritis is a common problem, but often underdiagnosed and undertreated in primary care as compared to evidence-based guidelines. Educational outreach visits are an effective strategy to improve guideline adherence, but its ...

Auteurs: David Spitaels, Rosella PMG Hermens, Frank P Luyten, Hilde Vandenneucker, Bert Aertgeerts, Sabine Verschueren, Dieter Van Assche, and Patrik Vankrunkelsven

1 March 2019 | ARTICLE

Dementia and road traffic accidents among non-institutionalized older people in Denmark: A Danish register-based nested case-control study.

AIM: We used register-based data to estimate the effect of all-type dementia on road traffic accidents (RTAs) risk, combined with comorbidities or sedative medicines, among non-institutionalized older people in Denmark. METHODS: The source populat...

Auteurs: Jindong Ding Petersen, Volkert Dirk Siersma, René Depont Christensen, Maria Munch Storsveen, Connie Thurøe Nielsen, Mikkel Vass, and Frans Boch Waldorff

1 March 2019 | ARTICLE

You never walk alone: An exploratory study of the needs and burden of an informal care group

Little is known about the dynamics of a group of people giving informal care together. The aim of this study was to investigate the characteristics of an informal care group, the obstacles the informal care group experiences, the needs and desires...

Auteurs: Leontien Jansen, Lieze Eecloo, Anneleen Vanwing, and Birgitte Schoenmakers

1 March 2019 | ARTICLE

Relational aspects of mastery for frail, older adults: The role of informal caregivers in the care process

Frail, older care recipients are often thought of as individuals with a decreased mastery of everyday life skills. Various authors have proposed to acknowledge a relational dimension of mastery, defined as the ability to maintain control over one'...

Auteurs: Deborah Lambotte, Martinus JM Kardol, Birgitte Schoenmakers, Bram Fret, An-Sofie Smetcoren, Ellen E De Roeck, Michael Van der Elst, and Liesbeth De Donder

19 February 2019 | ARTICLE

Early integrated palliative care in chronic heart failure and chronic obstructive pulmonary disease: protocol of a feasibility before-after intervention study.

Background: Patients with chronic heart failure (CHF) and patients with chronic obstructive pulmonary disease (COPD) are amenable to integrated palliative care (PC); however, despite the recommendation by various healthcare organizations, these pa...

Auteurs: N Siouta, A Heylen, B Aertgeerts, P Clement, J Van Cleemput, W Janssens, and J Menten

14 February 2019 | ARTICLE

Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia

OBJECTIVE: Morphine is a commonly used drug in encephalopathic neonates treated with therapeutic hypothermia after perinatal asphyxia. Pharmacokinetics and optimal dosing of morphine in this population are largely unknown. The objective of this st...

Auteurs: Laurent MA Favie, Floris Groenendaal, Marcel PH van den Broek, Carin MA Rademaker, Timo R de Haan, Henrica LM van Straaten, Peter H Dijk, Arno van Heijst, Jeroen Dudink, Koen P Dijkman, Monique Rijken, Inge A Zonnenberg, Filip Cools, Alexandra Zecic, Johanna H van der Lee, Debbie HGM Nuytemans, Frank van Bel, Toine CG Egberts, Alwin DR Huitema, Mieke J Brouwer, SM Mulder-de Tollenaer, LJM Groot Jebbink-Akkerman, Djien Liem, Katerina Steiner, Sinno HP Simons, Rogier CJ de Jonge, Annelies A Bos, Michel Sonnaert, and Fleur Anne Camfferman

2 February 2019 | ARTICLE

Are There Changes in Inequalities in Injuries? A Review of Evidence in the WHO European Region

Decreases in injury rates globally and in Europe in the past decades, although encouraging, may mask previously reported social inequalities between and within countries that persist or even increase. European research on this issue has not been s...

Auteurs: Mathilde Sengoelge, Merel Leithaus, Matthias Braubach, and Lucie Laflamme

1 February 2019 | ARTICLE

Couples Coping with Nutrition-Related Problems in Advanced Cancer. A Qualitative Study in Primary Care.

Purpose: Nutrition-related problems are common in patients with advanced cancer. They can disrupt daily life and routines. This study aimed to explore how couples cope with this source of distress. Methods: A qualitative descriptive study design ...

Auteurs: Sophie Opsomer, Sofie Joossens, Claudia De Wit, Emelien Lauwerier, and Peter Pype

1 February 2019 | ARTICLE

Citation bias in the literature on dietary trans fatty acids and serum cholesterol

OBJECTIVE: Balanced citations are a necessary condition for a sound development of scientific knowledge, whereas selective citations may bias scientific consensus. In this study, we assess which determinants influenced the likelihood of being cite...

Auteurs: Miriam JE Urlings, Bram Duyx, Gerard MH Swaen, Lex M Bouter, and Maurice PA Zeegers

29 January 2019 | ARTICLE

Effect of Hydrocortisone Therapy Initiated 7 to 14 Days After Birth on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation A Randomized Clinical Trial

IMPORTANCE: Dexamethasone initiated after the first week of life reduces the rate of death or bronchopulmonary dysplasia (BPD) but may cause long-term adverse effects in very preterm infants. Hydrocortisone is increasingly used as an alternative, ...

Auteurs: Wes Onland, Filip Cools, Andre Kroon, Karin Rademaker, Maruschka P Merkus, Peter H Dijk, Henrica L van Straaten, Arjan B Te Pas, Thilo Mohns, Els Bruneel, Arno F van Heijst, Boris W Kramer, Anne Debeer, Inge Zonnenberg, Yoann Marechal, Henry Blom, Katleen Plaskie, Martin Offringa, Anton H van Kaam, Debbie H Nuytemans, Moniek van de Loo, E Marleen Kemper, Inez Vereeck, Marja van der Heide-Jalving, Ellen de Kort, Eric Cavartorta, Anne Rassart, An Eerdekens, Margriet Stuijvenberg, Rene Matthijsse, Willem de Boode, Hendrik Niemarkt, Ilse van Hattum, Liesbeth Groot Jebbink, Susanne M Mulder-de Tollenaer, Ratna Tan, Claire Theyskens, Mirjam van Weissenbruch, Elke Dierckx, Vincent Rigo, Elianne Vrijlandt, Ingeborg van der Tweel, Caroline van Baal, and Saskia de Wildt

18 January 2019 | ARTICLE

Evaluation of the maternal deaths surveillance and response system at the health district level in Guinea in 2017 through digital communication tools.

BACKGROUND: Reducing maternal mortality still remains a major challenge in low-income countries. This study aims to explore how digital communication tools can be used to evaluate the maternal deaths surveillance and response (MDSR) system at the ...

Auteurs: Tamba Mina Millimouno, Sidikiba Sidibé, Alexandre Delamou, Olatoyossi Akanke Kefilath Bello, Jean-Paul Dossou, Basile Keugoung, Abdoul Habib Beavogui, and Bruno Meesen

10 January 2019 | OTHER

The Burden of Comorbidity in Patients with RA, PSA or SPA in a General Practice Registry

Auteurs: Sofia Pazmino, Veerle Stouten, Patrick Verschueren, Pavlos Mamouris, Rene Westhovens, Kurt De Vlam, Delphine Bertrand, Kristien Van der Elst, Bert Vaes, and Diederik De Cock

6 January 2019 | OTHER

INCIDENCE OF RHEUMATOID ARTHRITIS, PSORIATIC ARTHRITIS AND SPONDYLOARTHRITIS AND THEIR ASSOCIATED COMORBIDITIES IN A BELGIAN GP REGISTRY

Auteurs: Sofia Pazmino, Veerle Stouten, Patrick Verschueren, Pavlos Mamouris, Rene Westhovens, Kurt de Vlam, Delphine Bertrand, Kristien Van der Elst, Bert Vaes, and Diederik De Cock

6 January 2019 | ARTICLE

Burden of heart failure in Flemish general practices: a registry-based study in the Intego database

OBJECTIVES: To assess the prevalence and incidence of heart failure (HF) stages A to C/D and their evolution over a 16-year period. Additionally, trends in comorbidities and cardiovascular (CV) treatment in patients with HF were studied in the ...

Auteurs: Miek Smeets, Bert Vaes, Pavlos Mamouris, Marjan Van den Akker, Gijs Van Pottelbergh, Geert Goderis, Stefan Janssens, Bert Aertgeerts, and Severine Henrard

5 January 2019 | ARTICLE

Assessing testing rates for viral hepatitis B and C by general practitioners in Flanders, Belgium: a registry-based study

OBJECTIVES: Chronic infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) have a major impact on mortality worldwide. Although effective treatments are available for both HBV and HCV infection, < /50% of the patients are even d...

Auteurs: Rob Bielen, Ozgur M Koc, Dana Busschots, Geert Robaeys, Bert Aertgeerts, Bert Vaes, Pavlos Mamouris, Catharina Mathei, Geert Goderis, and Frederik Nevens

1 January 2019 | ARTICLE

The health and economic impact of acute gastroenteritis in Belgium, 2010-2014

Acute gastroenteritis (AGE) remains a common condition in both low- and high-income countries. In Belgium, however, there is currently a lack of information on the societal health and economic impact of AGE. We conducted a retrospective study u...

Auteurs: Theofilos Papadopoulos, Sofieke Klamer, Stephanie Jacquinet, Boudewijn Catry, Amber Litzroth, Laure Mortgat, Pavlos Mamouris, Javiera Rebolledo, Bert Vaes, Dieter Van Cauteren, Johan Van Der Heyden, Philippe Beutels, and Brecht Devleesschauwer

1 January 2019 | ARTICLE

Patient- and tumor-related predictors of chemotherapy intolerance in older patients with cancer: A systematic review

OBJECTIVE: The aim of this systematic review was to investigate patient-related factors (e.g. depressive symptoms, cognition, mobility, activities of daily living (ADL)) as well as tumor-related factors (e.g. tumor type, chemotherapy regimen) infl...

Auteurs: Doris L van Abbema, Marjan van den Akker, Maryska L Janssen-Heijnen, Franchette van den Berkmortel, Ann Hoeben, Judith de Vos-Geelen, Frank Buntinx, Jos Kleijnen, and Vivianne CG Tjan-Heijnen

1 January 2019 | ARTICLE

Wat betekent een beslishulp over menopauze in de praktijk?

Auteurs: Birgitte Schoenmakers, Arne Hens, Karolien Lenssen, Valerie Van Praet, and Sappho Walravens

1 January 2019 | ARTICLE

Tar, nicotine and carbon monoxide yield of UK cigarettes and the risk of non-muscle-invasive and muscle-invasive bladder cancer

Cigarette smoking is a major risk factor for bladder cancer (BC); however, the impact of cigarette content remains unclear. This study aims to investigate tar, nicotine and carbon monoxide (TNCO) yields of different filtered cigarettes in relation...

Auteurs: Frits HM van Osch, Charlotte GGM Pauwels, Sylvia HJ Jochems, Ranti Fayokun, Nicholas D James, D Michael A Wallace, Kar-keung Cheng, Richard T Bryan, Frederik J van Schooten, and Maurice P Zeegers

1 January 2019 | OTHER

Integrated care for the inhabitants of the city Leuven: Protocol of the ZORGZAAM Leuven integrated care project.

In Flanders, the prevalence of chronic diseases is high and still increasing partially due to aging of the population and partially due to other reasons like surviving acute diseases or cancer. The aim of the Zorgzaam Leuven project is to test the...

Auteurs: Gijs Van Pottelbergh and Marie Vandeputte