Publicaties

Een overzicht van alle publicaties van de onderzoekers bij Intego

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22 September 2021 | ARTICLE

Impact of comorbidities on physical function and survival of middle-aged, as compared to older, individuals with cancer

PURPOSE: To investigate if comorbidity predicts mortality and functional impairment in middle-aged individuals with cancer (50-64 years) as compared to older individuals. METHODS: A prospective cohort study. Outcomes were mortality and functional ...

Auteurs: Bogda Koczwara, Laura Deckx, Shahid Ullah, and Marjan van den Akker

17 September 2021 | ARTICLE

An automated data cleaning method for Electronic Health Records by incorporating clinical knowledge

BACKGROUND: The use of Electronic Health Records (EHR) data in clinical research is incredibly increasing, but the abundancy of data resources raises the challenge of data cleaning. It can save time if the data cleaning can be done automaticall...

Auteurs: Xi Shi, Charlotte Prins, Gijs Van Pottelbergh, Pavlos Mamouris, Bert Vaes, and Bart De Moor

9 September 2021 | ARTICLE

« Reablement » comme outil thérapeutique pour offrir aux personnes âgées une vie de qualité à domicile après une réadaptation gériatrique

Auteurs: Ines Mouchaers, JCM Van Haastregt, Hilde Verbeek, GIJM Kempen, Ellen Vlaeyen, Geert Goderis, and SF Metzelthin

7 September 2021 | ARTICLE

Association of Thyroid Dysfunction With Cognitive Function An Individual Participant Data Analysis

IMPORTANCE: In clinical guidelines, overt and subclinical thyroid dysfunction are mentioned as causal and treatable factors for cognitive decline. However, the scientific literature on these associations shows inconsistent findings. OBJECTIVE: To ...

Auteurs: Nicolien A van Vliet, Diana van Heemst, Osvaldo P Almeida, Bjorn O Asvold, Carole E Aubert, Jong Bin Bae, Linda E Barnes, Douglas C Bauer, Gerard J Blauw, Carol Brayne, Anne R Cappola, Graziano Ceresini, Hannie C Comijs, Jean-Francois Dartigues, Jean-Marie Degryse, Robin PF Dullaart, Marlise EA van Eersel, Wendy PJ den Elzen, Luigi Ferrucci, Howard A Fink, Leon Flicker, Hans J Grabe, Ji Won Han, Catherine Helmer, Martijn Huisman, M Arfan Ikram, Misa Imaizumi, Renate T de Jongh, J Wouter Jukema, Ki Woong Kim, Lewis H Kuller, Oscar L Lopez, Simon P Mooijaart, Jae Hoon Moon, Elisavet Moutzouri, Matthias Nauck, Jim Parle, Robin P Peeters, Mary H Samuels, Carsten O Schmidt, Ulf Schminke, P Eline Slagboom, Eystein Stordal, Bert Vaes, Henry Volzke, Rudi GJ Westendorp, Michiko Yamada, Bu B Yeap, Nicolas Rodondi, Jacobijn Gussekloo, and Stella Trompet

1 September 2021 | ARTICLE

Medical cannabis for chronic pain: a clinical practice guideline

CLINICAL QUESTION: What is the role of medical cannabis or cannabinoids for people living with chronic pain due to cancer or non-cancer causes? CURRENT PRACTICE: Chronic pain is common and distressing and associated with considerable socioeconomic...

Auteurs: Jason W Busse, Patrick Vankrunkelsven, Linan Zeng, Anja Fog Heen, Arnaud Merglen, Fiona Campbell, Lars-Petter Granan, Bert Aertgeerts, Rachelle Buchbinder, Matteo Coen, David Juurlink, Caroline Samer, Reed AC Siemieniuk, Nimisha Kumar, Lynn Cooper, John Brown, Lyubov Lutvyn, Dena Zeraatkar, Li Wang, Gordon H Guyatt, Per O Vandvik, and Thomas Agoritsas

1 September 2021 | ARTICLE

Clinical Features for the Diagnosis of Pediatric Urinary Tract Infections: Systematic Review and Meta-Analysis

PURPOSE: Accurate diagnosis of urinary tract infection in children is essential because children left untreated can experience permanent renal injury. We aimed to assess the diagnostic value of clinical features of pediatric urinary tract infectio...

Auteurs: Hanne A Boon, Ann Van den Bruel, Thomas Struyf, Andreas Gillemot, Dominique MA Bullens, and Jan Y Verbakel

1 September 2021 | OTHER

The scale-up of integrated heart failure care in flanders: protocol of a learning network case study

Auteurs: M Smeets, W Raat, W Van Den Noortgate, H Vandenhoudt, K Baldewijns, J Van Olmen, and B Vaes

1 September 2021 | ARTICLE

Frequency of Renal Monitoring - Creatinine and Cystatin C (FORM-2C): an observational cohort study of patients with reduced eGFR in primary care

BACKGROUND: Monitoring is the mainstay of chronic kidney disease management in primary care; however, there is little evidence about the best way to do this. AIM: To compare the effectiveness of estimated glomerular filtration rate (eGFR) derived ...

Auteurs: Susannah Fleming, Rafael Perera-Salazar, Kathryn S Taylor, Louise Jones, FD Richard Hobbs, Tim James, Chris A O'Callaghan, Brian Shine, Jan Y Verbakel, Richard Stevens, and Clare Bankhead

21 August 2021 | ARTICLE

"I must, and I can live with that": a thematic analysis of patients' perspectives on polypharmacy and a digital decision support system for GPs

BACKGROUND: To investigate patients' perspectives on polypharmacy and the use of a digital decision support system to assist general practitioners (GPs) in performing medication reviews. METHODS: Qualitative interviews with patients or informal ca...

Auteurs: Robin Bruenn, Beate S Mueller, Benno Flaig, Petra Kellermann-Muehlhoff, Ute Karbach, Sara Soeling, Christiane Muth, and Marjan van den Akker

9 August 2021 | ARTICLE

The effect of a case-finding app on the detection rate of atrial fibrillation compared with opportunistic screening in primary care patients: protocol for a cluster randomized trial

BACKGROUND: Atrial fibrillation is a cardiac arrhythmia commonly encountered in a primary care setting. Current screening is limited to pulse palpation and ECG confirmation when an irregular pulse is found. Paroxysmal atrial fibrillation will, how...

Auteurs: Simon Gabriel Beerten, Tine Proesmans, and Bert Vaes

6 August 2021 | TEXT RESOURCE

EBP informatiebron noodanticonceptie (Mei 2021)

Auteurs: Michael Ceulemans, Thierry Christiaens, Isabelle De Wulf, Hélène Marsily, Lieve Peremans, Jan Verbakel, and Veerle Foulon

1 August 2021 | ARTICLE

Efficiency, Usability, and Outcomes of Proctored Next-Level Exams for Proficiency Testing in Primary Care Education: Observational Study

BACKGROUND: The COVID-19 pandemic has affected education and assessment programs and has resulted in complex planning. Therefore, we organized the proficiency test for admission to the Family Medicine program as a proctored exam. To prevent fraud,...

Auteurs: Birgitte Schoenmakers and Johan Wens

1 August 2021 | ARTICLE

Long-term monitoring in primary care for chronic kidney disease and chronic heart failure: a multi-method research programme

Background

Long-term monitoring is important in chronic condition management. Despite considerable costs of monitoring, there is no or poor evidence on how, what and when to monitor. The aim of this study was to improve understanding, meth...

Auteurs: R Perera, R Stevens, JK Aronson, A Banerjee, J Evans, BG Feakins, S Fleming, P Glasziou, C Heneghan, FDR Hobbs, L Jones, M Kurtinecz, DS Lasserson, L Locock, J McLellan, B Mihaylova, CA O’Callaghan, JL Oke, N Pidduck, A Plüddemann, N Roberts, I Schlackow, B Shine, CL Simons, CJ Taylor, KS Taylor, JY Verbakel, and C Bankhead

1 August 2021 | OTHER

Systematic Review and Metaanalysis Comparing the Bias and Accuracy of the Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration Equations in Community-Based Populations (vol 64, pg 475, 2018)

Auteurs: Emily C McFadden, Jennifer A Hirst, Jan Y Verbakel, Julie H McLellan, FD Richard Hobbs, Richard J Stevens, Chris A O'Callaghan, and Daniel S Lasserson

20 July 2021 | OTHER

De Eerstelijnszorg van de toekomst is met verpleegkundigen in de huisartsenpraktijken

Vlaamse wetenschappers vragen de beleidsmakers snel werk te maken van een regelgevend kader (en een licht aangepaste financiering) rond de inzet van verpleegkundigen in de huisartsenpraktijken. Het zal de kwaliteit van de eerstelijnszorg verbeteren.

Auteurs: Karolien Baldewijns, Miek Smeets, Hilde Vandenhoudt, Katrien Danhieux, Monika Martens, Lucky Botteldoren, Peter van de Bogaert, Roy Remmen, and Josefien van Olmen

19 July 2021 | ARTICLE

Supporting an informal care group - Social contacts and communication as important aspects in the psychosocial well-being of informal caregivers of older patients in Belgium

BACKGROUND: Increasingly, informal caregivers in Belgium care in group for an older patient. This study aimed to decrease the caregiver burden and to increase the well-being of caregivers and patients by supporting the needs of informal care group...

Auteurs: Leontien Jansen, Tine De Burghgraeve, Marjan van den Akker, Frank Buntinx, and Birgitte Schoenmakers

17 July 2021 | ARTICLE

Outpatient urine collection methods for paediatric urinary tract infections: Systematic review of diagnostic accuracy studies

AIM: To investigate the diagnostic test accuracy of urine collection methods for urinary tract infections in outpatient children. METHODS: A systematic literature review until April 2021 (Medline, Web of Science, Embase, Cinahl) to examine the dia...

Auteurs: Hanne Ann Boon, Wouter Lenaerts, Cedric Van Aerde, and Jan Y Verbakel

16 July 2021 | ARTICLE

Implementing standards of care for heart failure patients in general practice - the IMPACT-B study protocol

BACKGROUND: Heart failure (HF) is an important health problem. Most chronic HF management occurs in primary care. Although guidelines exist, there is an important implementation gap in current HF care in Belgium. METHODS: We will conduct a non-ran...

Auteurs: Willem Raat, Miek Smeets, Gijs Van Pottelbergh, Marie van de Putte, Stefan Janssens, and Bert Vaes

9 July 2021 | ARTICLE

Perspectives of older adults with a chronic condition on functioning, social participation and health: a qualitative study

BACKGROUND: Problems with mobility, functioning and social participation make living independently difficult for frail older adults. To continue living independently, therapy adherence is a prerequisite. The causes for non-adherence among older ad...

Auteurs: Leen De Coninck, Anja Declercq, Leen Bouckaert, Mieke Vermandere, Maud JL Graff, and Bert Aertgeert

8 July 2021 | ARTICLE

Electrophysiological proxy of cognitive reserve index

Cognitive reserve (CR) postulates that individual differences in task performance can be attributed to differences in the brain's ability to recruit additional networks or adopt alternative cognitive strategies. Variables that are descriptive of l...

Auteurs: Elvira Khachatryan, Benjamin Wittevrongel, Matej Perovnik, Jos Tournoy, Birgitte Schoenmakers, and Marc Van Hulle

8 July 2021 | ARTICLE

Lack of Cost-Effectiveness of Preoperative Erythropoiesis-Stimulating Agents and/or Iron Therapy in Anaemic, Elective Surgery Patients: A Systematic Review and Updated Analysis

OBJECTIVES: For anaemic elective surgery patients, current clinical practice guidelines weakly recommend the routine use of iron, but not erythrocyte-stimulating agents (ESAs), except for short-acting ESAs in major orthopaedic surgery. This recomm...

Auteurs: Bert Avau, Hans Van Remoortel, Jorien Laermans, Geertruida Bekkering, Dean Fergusson, Jorgen Georgsen, Paola Maria Manzini, Yves Ozier, Emmy De Buck, Veerle Compernolle, and Philippe Vandekerckhove

4 July 2021 | ARTICLE

The Management of Dementia by Flemish GPs: it Remains a Difficult Job

OBJECTIVE: The following study examines how GPs in Flanders deal with dementia in terms of detection, diagnosis, care diagnosis and treatment. METHODS: An online survey was sent out by mail to 5113 Flemish GP’s. Data were collected from February 1...

Auteurs: Jan De Lepeleire, Delphine Despriet, Eilien Van De Putte, Herlinde Van Eecke, Jan Steyaert, and Birgitte Schoenmakers

1 July 2021 | OTHER

Evaluation of the Fibrosis-4 score for referral from primary care patients for NAFLD in Belgium

Auteurs: Leen Heyens, Dana Busschots, Judith Wellens, Marlies Devos, Luc Present, Birgitte Schoenmakers, Kitty De Munck, Eva Rubens, Katrien Joris, Roy Remmen, Anouk Bongaerts, Karen Breure, Frederik Vanstraelen, Valerie Vos, Tom Bijnens, Inge Houben, Sanne Bertels, Lisa Vanbrabant, Yoni Groenendaels, Liesbeth Vernijns, Anneleen Robaeys, Thomas De Somer, Ger Koek, Sven Francque, Christophe Van Steenkiste, and Geert Robaeys

1 July 2021 | ARTICLE

Primary care implementation study to scale up early identification and brief intervention and reduce alcohol-related negative outcomes at the community level (PINO): study protocol for a quasi-experimental 3-arm study

Background Primary healthcare-based Early Identification and Brief Intervention (EIBI) for hazardous and harmful alcohol use is both a clinically relevant and cost-effective strategy to reduce heavy drinking. Unfortunately, it remains poorly imple...

Auteurs: Bram Pussig, Lodewijk Pas, Ann Li, Mieke Vermandere, Bert Aertgeerts, and catharina Matheï

30 June 2021 | ARTICLE

The Relation between Age of Retirement and Frailty in Later Life? A Cross-Sectional Study in Flemish Older Adults

BACKGROUND: Policymakers in several European countries, concerned about the sustainability of their pension system, have raised the statutory retirement age. While several studies investigated the effect of retirement on health, the relationship b...

Auteurs: Michaël Christiaan John Van der Elst, Birgitte Schoenmakers, Dominique Verté, Liesbeth De Donder, Nico De Witte, Sarah Dury, Bram Fret, Jeroen Luyten, Jos Schols, Kempen Gertrudis, and Jan De Lepeleire

29 June 2021 | OTHER

The Development of a Belgian Prospective Data Registration System on Perinatal Medication Use and Mother-Infant Outcomes: an introduction to the BELpREG initiative

Auteurs: Laure Sillis, Michael Ceulemans, Kristel Van Calsteren, Anne Smits, Titia Hompes, Annick Bogaerts, Karel Allegaert, Maarten De Vos, Jan Verbakel, and Veerle Foulon

29 June 2021 | OTHER

Machine learning optimization of an electronic health record audit to improve heart failure identification in primary care

Auteurs: Willem Raat, Miek Smeets, Severine Henrard, Bert Aertgeerts, Stefan Janssens, and Bert Vaes

22 June 2021 | ARTICLE

Effect of exergaming on wellbeing of residents in a nursing home: a single blinded intervention study

INTRODUCTION: To improve the quality of life in nursing homes, meaningful activities and social contact are indispensable. Exergames can play a role addressing these needs. METHODS: In a randomized single blinded controlled intervention study, we ...

Auteurs: Marlies Gunst, Isabelle De Meyere, Hannah Willems, and Birgitte Schoenmakers

21 June 2021 | ARTICLE

Prevalence of Atherosclerotic Cardiovascular Disease, Heart Failure, and Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus: A Primary Care Research Network-based Study

AIMS: This study aims to assess the prevalence of atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), chronic kidney disease (CKD), and their combined presence in type 2 diabetes (T2D) patients in primary care for whom the 2019 ...

Auteurs: Geert Goderis, Bert Vaes, Pavlos Mamouris, Eline van Craeyveld, and Chantal Mathieu

18 June 2021 | OTHER

Learning health care network heart failure: towards a better heart failure care in Belgium

Auteurs: Karolien Baldewijns, Miek Smeets, and Hilde Vandenhoudt